Genome-Scale Algorithm Design
Genome-Scale Algorithm Design High-throughput sequencing has revolutionised the field of biological sequence analysis. This book provides an integrated presentation of the fundamental algorithms and…
Specifikacia Genome-Scale Algorithm Design
Genome-Scale Algorithm Design
High-throughput sequencing has revolutionised the field of biological sequence analysis. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. Its application has enabled researchers to address important biological questions, often for the first time.
The chapters feature numerous examples, algorithm visualisations, exercises and problems, each chosen to reflect the steps of large-scale sequencing projects, including read alignment, variant calling, haplotyping, fragment assembly, alignment-free genome comparison, transcript prediction and analysis of metagenomic samples. The topics covered range from the foundations of biological sequence analysis (alignments and hidden Markov models), to classical index structures (k-mer indexes, suffix arrays and suffix trees), Burrows–Wheeler indexes, graph algorithms and a number of advanced omics applications. Each biological problem is accompanied by precise formulations, providing graduate students and researchers in bioinformatics and computer science with a powerful toolkit for the emerging applications of high-throughput sequencing.