Drug-Drug Interactions
Drug-Drug Interactions Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Traditionally, DDI have been…
Specifikacia Drug-Drug Interactions
Drug-Drug Interactions
Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient.
In addition, novel mechanisms of regulating DDIs can also be suggested. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In the case of the substance targeted for interaction, not only the DDIs but also the herb-drug or food-drug interactions have been reported to be clinically relevant in terms of
Drug-Drug Interactions
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