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Cancer Clinical Trials

The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, however, still raise methodological problems that are important and at the same…

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Specifikacia Cancer Clinical Trials


The controlled clinical trial has become an essential part of the clinician's decision-making process. Clinical trials, however, still raise methodological problems that are important and at the same time controversial: subgroup analysis and interactions, meta-analy- sis of similar trials, consideration of subjective clinical opinions and those of the public at large, assessment of quality of life, pre- vention trials, and so on. In February 1987 we took our third step along the road to evaluating these issues in dialogues between cli- nicians, psychologists, legal experts, and statisticians. The talks presented at the meeting were revised by the authors afterwards and have been rearranged by the editors to form a strictly organ- 1 2 ized book. The two preceding meetings in 1978 and 1981 focused strongly on adjuvant therapy in primary breast cancer, but this top- ic served merely as a

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