Arbidol: an antiviral against globally prevalent viruses
Arbidol: an antiviral against globally prevalent viruses Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and…
Specifikacia Arbidol: an antiviral against globally prevalent viruses
Arbidol: an antiviral against globally prevalent viruses
Antiviral drug development has led to significant advances in the control of globally prevalent viral infections by the hepatitis C (HCV) and the human immunodeficiency viruses. Arbidol (ARB) is a cost-effective antiviral with broad-spectrum activity, administered for decades in Russia and China against flu. Nonetheless, there are current gaps in the armamentarium against global viral infections due to some herpes viruses, the hepatitis B virus, and the deadly filovirus Ebola and arenavirus Tacaribe responsible of outbreaks of hemorrhagic fever in emerging countries.
Since these viruses have divergent life cycles, we posit that ARB may exhibit varied modes of action against different viruses. We showed that ARB inhibits HCV infection, and has potent antiviral activity against the Ebola, Tacaribe, hepatitis B and human herpes-8 viruses. Careful dissection of molecular mechanisms of