25 Years of p53 Research - Pierre Hainaut, Klas G. Wiman
25 Years of p53 Research - Pierre Hainaut, Klas G. Wiman The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology, an era that is…
Specifikacia 25 Years of p53 Research - Pierre Hainaut, Klas G. Wiman
25 Years of p53 Research - Pierre Hainaut, Klas G. Wiman
The discovery of p53 in 1979 marks the beginning of a most fascinating era of modern cancer research and molecular biology, an era that is still in full swing and does not show any signs of ending in the foreseeable future. For around 10 years, p53 was considered an oncogene with somewhat unusual features. p53 has emerged as a key tumor suppressor and important target for novel cancer therapy.
However, a major paradigm shift occurred around 1988-89 when exciting new findings demonstrated that normal (wild type) p53 could inhibit transformation of cells in culture and that the p53 gene was muta
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